pentobarbital will lessen the level or result of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers lessens plasma focus of abemaciclib and its metabolites.Signs special to seizure and seizures auras are depression, a feeling of heaviness, a